As the dire wolves almost always hunt in packs it can be difficult to escape them if you encounter early game. Because of their pack skills they will try to surround you, the easiest way I've found is to run to a high place that they cannot reach you or climb(such as a boulder) And stand there, if you have a long range weapon you can start to pick them off one by one. Due to low health it is relatively easy to kill the beasts.
I watched a pack of these killers destroy a rex but some of them died in the process but I tried to take them on myself and nearly died. NEVER and I mean NEVER underestimate the power of these killer dogs.