One time on SE I was playing and I found 2 Direwolves so I went up to one with my boomerang it was level 20 and I accidentally killed it while trying to knock it out,yet the other one was level 1 and I onocked it out and killed it by accident as well
Moral of the Story:Boomerangs can kill direwolves at melee distance
You can expect your snow base to be frequently harrassed by these guys. Build spike walls around your base to keep them out or at least make it easier for your tames to take them out. Never go out alone, even a lone mammoth is likely to die from a pack. Unlike raptors or sabers they get a pack bonus like compies, and they get an alpha buff. Shotgun can easily drop individuals.
South 1 on ragnorak is best place to tame finding solo wolves to a abundant amount, I would suggest a pen to trap with resources set by. Atone is best, Rock Holes tend to pop up here and there near by locations though they stick out easily, you can find sheep all over the area for mutton giving up to 35 on official servers.
DO NOT take a group of these on by yourself without tames and without bolas, if your movement speed is low and your stamina is too, nine times out of ten you will die. If you are going to go out in a dangerous area on foot, be sure to always take bolas with you as one hit to a dire wolf immobilises them for quite some time, allowing you to escape unharmed. If you want to kill one of these bad boys I would still suggest using bolas, however once bola'd do not attack it from the front as it will still take a chunk out of you. Just strike it from the side or behind. I would only suggest taking a group of these things on with multiple people or multiple high level tames(preferably heavy hitters).
another great use if you have a direwolf bring it with you on a tame, use an argy to fly it over drop it near a safe area bring down your target then use the wolf to get prime meat easy tame and I guarantee nothing will kill your tame you spent 8 hours on with the wolf around!