DO NOT take a group of these on by yourself without tames and without bolas, if your movement speed is low and your stamina is too, nine times out of ten you will die. If you are going to go out in a dangerous area on foot, be sure to always take bolas with you as one hit to a dire wolf immobilises them for quite some time, allowing you to escape unharmed. If you want to kill one of these bad boys I would still suggest using bolas, however once bola'd do not attack it from the front as it will still take a chunk out of you. Just strike it from the side or behind. I would only suggest taking a group of these things on with multiple people or multiple high level tames(preferably heavy hitters).
You can't escape them, so don't try, you can't fight them, so don't try, you can't help your level 999 specially bred mutated giga, so don't try, just stand calmly and don't try to fight, just let the wolves eat you, at least then you'll have an interesting funeral being eaten by ravenous wolves.