DO NOT take a group of these on by yourself without tames and without bolas, if your movement speed is low and your stamina is too, nine times out of ten you will die. If you are going to go out in a dangerous area on foot, be sure to always take bolas with you as one hit to a dire wolf immobilises them for quite some time, allowing you to escape unharmed. If you want to kill one of these bad boys I would still suggest using bolas, however once bola'd do not attack it from the front as it will still take a chunk out of you. Just strike it from the side or behind. I would only suggest taking a group of these things on with multiple people or multiple high level tames(preferably heavy hitters).
tip dont get the high ground and expect them to be gone as soon as you do true fact wolves can wait for their prey to come down for a long time or if they are smart enough figure out your high ground schematic