While encountering this magnificent specimen . . I highly recommend a tranq gun and some tranq darts. Once you have knocked the wolf unconscious, Me and my tribe recommend to starve it out ( This is a good tactic for any tame ) Once it is starved, Dump a good source into it such as kibble, prime meat, mutton, Etc. Within a couple of minutes it should be tamed and you may now name your newly tamed direwolf . . !
You can't escape them, so don't try, you can't fight them, so don't try, you can't help your level 999 specially bred mutated giga, so don't try, just stand calmly and don't try to fight, just let the wolves eat you, at least then you'll have an interesting funeral being eaten by ravenous wolves.