If you have a shield, it can be used to block the Dilo's ranged attacks.

Killing these can drop a NERDY GLASSES SKIN at random

When beginning the game with a little shack done always bring a dodo with you so whenever you encounter the dilo and it spits throw the dodo at it To activate dodo shield

They make a distinct aggro sound when they lock onto you, keep this in mind when one is nearby. They are easily outrun and with very little practice you can avoid their arcing acid attack. Spears/arrows to he head are very effective