Nirvana Tonic can unlock all engrams in single-player, but multiplayer may require additional use, so plan carefully before consuming it. Use it only after reaching your desired progression, since following it with a Mindwipe Tonic can reset engrams, pursuits, and progression, making recovery difficult. Potent Dust can be obtained through renewable plant farming or artifact runs, while an Industrial Grinder is more efficient than a Mortar and Pestle for processing materials.